Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF678. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF678 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF678, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:227,317,661–227,319,447 | 245.1 kb | Distal (>10kb) Multiome | 860 | |
| chr1:227,541,755–227,542,988 | 20.9 kb | Distal (>10kb) Multiome | 600 | |
| chr1:227,563,282–227,564,196 | 199 bp | At TSS Multiome | 889 | |
| chr1:227,728,086–227,729,232 | 164.9 kb | Distal (>10kb) Multiome | 590 | |
| chr1:227,730,363–227,730,812 | 167.0 kb | Distal (>10kb) Multiome | 276 | |
| chr1:227,734,745–227,735,925 | 171.8 kb | Distal (>10kb) Multiome | 1052 | |
| chr1:227,787,209–227,789,037 | 224.7 kb | Distal (>10kb) Multiome | 579 |
Genomic view of the ZNF678 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.