Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF672. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF672 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF672, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:247,347,704–247,348,357 | 1490.2 kb | Distal (>10kb) Multiome HiCAR | 165 | |
| chr1:248,825,287–248,827,024 | 12.1 kb | Distal (>10kb) Multiome | 866 | |
| chr1:248,837,447–248,839,602 | 50 bp | At TSS Multiome | 979 | |
| chr1:248,841,747–248,842,009 | 2.7 kb | Proximal (<10kb) | 88 | |
| chr1:248,847,039–248,848,710 | 9.4 kb | Proximal (<10kb) Multiome | 242 | |
| chr1:248,857,587–248,859,802 | 19.8 kb | Distal (>10kb) Multiome | 984 | |
| chr1:248,862,776–248,863,977 | 25.1 kb | Distal (>10kb) Multiome | 625 | |
| chr1:248,872,599–248,874,733 | 35.8 kb | Distal (>10kb) Multiome | 1099 | |
| chr1:248,905,646–248,907,461 | 68.2 kb | Distal (>10kb) Multiome | 1045 |
Genomic view of the ZNF672 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.