Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF646. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF646 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF646, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:30,774,965–30,776,186 | 298.9 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,786,385–30,788,019 | 287.3 kb | Distal (>10kb) Multiome | 885 | |
| chr16:30,805,468–30,806,187 | 268.7 kb | Distal (>10kb) Multiome | 969 | |
| chr16:30,814,045–30,814,733 | 260.0 kb | Distal (>10kb) Multiome | 995 | |
| chr16:30,841,062–30,841,882 | 232.9 kb | Distal (>10kb) Multiome | 49 | |
| chr16:30,874,866–30,875,643 | 199.1 kb | Distal (>10kb) Multiome | 1108 | |
| chr16:30,893,485–30,894,587 | 180.2 kb | Distal (>10kb) Multiome | 950 | |
| chr16:30,895,854–30,897,426 | 177.4 kb | Distal (>10kb) Multiome | 822 | |
| chr16:30,901,969–30,902,794 | 172.1 kb | Distal (>10kb) Multiome | 579 | |
| chr16:30,921,611–30,925,097 | 151.0 kb | Distal (>10kb) Multiome | 1132 | |
| chr16:30,927,705–30,928,596 | 146.3 kb | Distal (>10kb) Multiome | 274 | |
| chr16:30,941,803–30,942,254 | 132.3 kb | Distal (>10kb) Multiome | 507 | |
| chr16:30,947,471–30,950,635 | 124.2 kb | Distal (>10kb) Multiome | 1066 | |
| chr16:30,953,370–30,954,135 | 120.6 kb | Distal (>10kb) Multiome | 499 | |
| chr16:30,956,960–30,958,498 | 116.7 kb | Distal (>10kb) Multiome | 1022 | |
| chr16:30,984,837–30,985,709 | 89.2 kb | Distal (>10kb) Multiome | 787 | |
| chr16:30,996,877–30,998,001 | 77.0 kb | Distal (>10kb) Multiome | 759 | |
| chr16:31,010,379–31,011,032 | 63.7 kb | Distal (>10kb) Multiome | 117 | |
| chr16:31,032,789–31,034,448 | 40.9 kb | Distal (>10kb) Multiome | 1047 | |
| chr16:31,041,996–31,042,665 | 32.1 kb | Distal (>10kb) Multiome | 213 | |
| chr16:31,072,597–31,074,957 | 961 bp | At TSS Multiome | 1167 | |
| chr16:31,094,132–31,095,139 | 20.4 kb | Distal (>10kb) Multiome | 933 | |
| chr16:31,108,209–31,108,826 | 34.0 kb | Distal (>10kb) Multiome | 733 | |
| chr16:31,117,128–31,118,265 | 43.3 kb | Distal (>10kb) Multiome | 929 | |
| chr16:31,134,682–31,136,040 | 61.3 kb | Distal (>10kb) Multiome | 450 | |
| chr16:31,138,695–31,139,457 | 64.7 kb | Distal (>10kb) Multiome | 413 | |
| chr16:31,141,455–31,143,270 | 68.0 kb | Distal (>10kb) Multiome | 856 | |
| chr16:31,148,229–31,148,775 | 74.0 kb | Distal (>10kb) Multiome | 209 | |
| chr16:31,179,340–31,181,495 | 105.6 kb | Distal (>10kb) Multiome | 1179 | |
| chr16:31,201,568–31,203,049 | 127.8 kb | Distal (>10kb) Multiome | 507 | |
| chr16:31,214,606–31,216,091 | 140.9 kb | Distal (>10kb) Multiome | 469 |
Genomic view of the ZNF646 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.