Transcription factors with Perturb-seq knockdown data for ZNF470-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF470-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF470-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:56,314,052–56,315,623 | 252.4 kb | Distal (>10kb) Multiome | 844 | |
| chr19:56,346,962–56,347,557 | 220.1 kb | Distal (>10kb) Multiome | 97 | |
| chr19:56,367,790–56,368,666 | 199.2 kb | Distal (>10kb) Multiome | 609 | |
| chr19:56,393,166–56,393,951 | 173.9 kb | Distal (>10kb) Multiome | 653 | |
| chr19:56,403,714–56,404,765 | 163.2 kb | Distal (>10kb) Multiome | 745 | |
| chr19:56,566,944–56,568,046 | 92 bp | At TSS Multiome | 436 | |
| chr19:56,594,882–56,595,857 | 27.9 kb | Distal (>10kb) Multiome | 635 |
Genomic view of the ZNF470-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.