Enables SUMO ligase activity; transcription corepressor activity; and transcription regulator inhibitor activity. Involved in negative regulation of transcription initiation by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Located in PML body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF451. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF451 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF451, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:56,842,688–56,844,659 | 246.1 kb | Distal (>10kb) Multiome | 779 | |
| chr6:56,851,156–56,852,284 | 238.2 kb | Distal (>10kb) Multiome | 359 | |
| chr6:56,953,824–56,956,167 | 134.9 kb | Distal (>10kb) Multiome | 903 | |
| chr6:57,046,297–57,047,003 | 43.4 kb | Distal (>10kb) Multiome | 808 | |
| chr6:57,082,631–57,083,280 | 6.8 kb | Proximal (<10kb) | 16 | |
| chr6:57,089,489–57,090,518 | 41 bp | At TSS Multiome | 913 | |
| chr6:57,171,958–57,173,533 | 82.6 kb | Distal (>10kb) Multiome | 1049 | |
| chr6:57,221,224–57,222,970 | 131.6 kb | Distal (>10kb) Multiome | 867 | |
| chr6:57,316,348–57,318,082 | 227.6 kb | Distal (>10kb) Multiome | 828 | |
| chr6:57,318,958–57,320,128 | 229.5 kb | Distal (>10kb) Multiome | 130 |
Genomic view of the ZNF451 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.