This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for ZNF444. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF444 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF444, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:56,120,040–56,122,160 | 19.9 kb | Distal (>10kb) Multiome | 1006 | |
| chr19:56,135,505–56,135,844 | 5.5 kb | Proximal (<10kb) | 19 | |
| chr19:56,136,421–56,136,752 | 4.5 kb | Proximal (<10kb) | 82 | |
| chr19:56,140,231–56,141,860 | 313 bp | At TSS Multiome | 744 | |
| chr19:56,217,208–56,217,951 | 76.3 kb | Distal (>10kb) Multiome | 116 | |
| chr19:56,314,052–56,315,623 | 173.7 kb | Distal (>10kb) Multiome | 844 | |
| chr19:56,346,962–56,347,557 | 206.0 kb | Distal (>10kb) Multiome | 97 | |
| chr19:56,367,790–56,368,666 | 226.9 kb | Distal (>10kb) Multiome | 609 | |
| chr19:56,393,166–56,393,951 | 252.2 kb | Distal (>10kb) Multiome | 653 | |
| chr19:56,403,714–56,404,765 | 262.9 kb | Distal (>10kb) Multiome | 745 |
Genomic view of the ZNF444 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.