ZNF443

zinc finger protein 443 | ZK1

Zinc finger proteins (ZNFs) bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. For a general description of these proteins, see ZNF91 (MIM 603971).[supplied by OMIM, Jul 2002]

Biological processes 7 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)apoptotic process (GO:0006915)nucleus (GO:0005634)nucleus (GO:0005634)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating ZNF443 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF443. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF443 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF443

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF443, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:12,156,210–12,156,965	284.3 kb	Distal (>10kb) Multiome	638
chr19:12,162,692–12,163,608	277.9 kb	Distal (>10kb) Multiome	697
chr19:12,365,585–12,366,054	75.3 kb	Distal (>10kb) Multiome	577
chr19:12,400,090–12,401,657	39.8 kb	Distal (>10kb) Multiome	671
chr19:12,440,217–12,441,483	47 bp	At TSS Multiome	565
chr19:12,484,131–12,485,387	43.8 kb	Distal (>10kb) Multiome	664
chr19:12,495,009–12,495,882	54.4 kb	Distal (>10kb) Multiome	824
chr19:12,550,951–12,551,971	110.5 kb	Distal (>10kb) Multiome	976
chr19:12,571,455–12,571,942	130.7 kb	Distal (>10kb) Multiome	36
chr19:12,610,516–12,611,613	169.9 kb	Distal (>10kb) Multiome	925
chr19:12,639,899–12,640,614	199.2 kb	Distal (>10kb) Multiome	454
chr19:12,647,538–12,648,022	206.7 kb	Distal (>10kb) Multiome	126
chr19:12,656,871–12,657,566	216.2 kb	Distal (>10kb) Multiome	254
chr19:12,666,317–12,667,225	225.7 kb	Distal (>10kb) Multiome	495
chr19:12,669,351–12,669,939	228.5 kb	Distal (>10kb) Multiome	777
chr19:12,681,003–12,682,117	240.4 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	255.6 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	262.2 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	281.4 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	283.1 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	293.7 kb	Distal (>10kb) Multiome	882
chr19:12,736,470–12,737,780	296.1 kb	Distal (>10kb) Multiome	742

Genome Browser

Genomic view of the ZNF443 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.