Enables DNA-binding transcription factor activity. Involved in negative regulation of DNA-templated transcription. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF438. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF438 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF438, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:30,783,902–30,784,662 | 247.9 kb | Distal (>10kb) Multiome | 300 | |
| chr10:30,784,858–30,785,789 | 246.6 kb | Distal (>10kb) Multiome | 462 | |
| chr10:30,830,080–30,831,172 | 201.3 kb | Distal (>10kb) Multiome | 178 | |
| chr10:31,029,749–31,029,983 | 2.0 kb | Proximal (<10kb) | 21 | |
| chr10:31,030,378–31,030,526 | 1.4 kb | Proximal (<10kb) | 46 | |
| chr10:31,030,970–31,033,079 | 233 bp | At TSS Multiome | 955 | |
| chr10:31,036,265–31,036,821 | 4.3 kb | Proximal (<10kb) | 183 | |
| chr10:31,133,357–31,134,908 | 102.1 kb | Distal (>10kb) Multiome | 531 | |
| chr10:31,318,167–31,321,185 | 287.3 kb | Distal (>10kb) Multiome | 858 |
Genomic view of the ZNF438 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.