The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for ZNF420. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF420 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF420, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:36,837,900–36,839,014 | 240.0 kb | Distal (>10kb) Multiome | 855 | |
| chr19:36,849,748–36,851,333 | 228.1 kb | Distal (>10kb) Multiome | 755 | |
| chr19:36,915,949–36,916,617 | 162.1 kb | Distal (>10kb) Multiome | 584 | |
| chr19:36,973,037–36,973,876 | 105.0 kb | Distal (>10kb) Multiome | 240 | |
| chr19:37,077,879–37,078,723 | 144 bp | At TSS Multiome | 859 | |
| chr19:37,217,536–37,218,551 | 139.6 kb | Distal (>10kb) Multiome | 914 | |
| chr19:37,370,849–37,371,460 | 292.6 kb | Distal (>10kb) Multiome | 857 |
Genomic view of the ZNF420 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.