Enables protein heterodimerization activity; protein homodimerization activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of DNA-templated transcription. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF396. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF396 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF396, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:35,240,066–35,241,553 | 136.3 kb | Distal (>10kb) Multiome | 906 | |
| chr18:35,289,760–35,290,683 | 87.1 kb | Distal (>10kb) Multiome | 970 | |
| chr18:35,343,705–35,344,835 | 33.0 kb | Distal (>10kb) Multiome | 916 | |
| chr18:35,370,885–35,371,262 | 6.1 kb | Proximal (<10kb) | 9 | |
| chr18:35,371,506–35,371,791 | 5.5 kb | Proximal (<10kb) | 14 | |
| chr18:35,376,423–35,377,702 | 105 bp | At TSS Multiome | 673 | |
| chr18:35,383,338–35,384,335 | 6.0 kb | Proximal (<10kb) | 17 | |
| chr18:35,386,614–35,387,208 | 9.3 kb | Proximal (<10kb) | 215 | |
| chr18:35,496,979–35,498,336 | 120.5 kb | Distal (>10kb) Multiome | 1055 | |
| chr18:35,580,775–35,581,562 | 204.2 kb | Distal (>10kb) Multiome | 563 |
Genomic view of the ZNF396 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.