Transcription factors with Perturb-seq knockdown data for ZNF385D-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF385D-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF385D-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:21,542,454–21,542,826 | at TSS | At TSS | 74 | |
| chr3:21,542,953–21,544,330 | 829 bp | At TSS Multiome | 330 | |
| chr3:21,547,219–21,547,613 | 4.4 kb | Proximal (<10kb) | 11 | |
| chr3:21,547,770–21,548,134 | 5.0 kb | Proximal (<10kb) | 12 | |
| chr3:21,749,994–21,752,164 | 208.4 kb | Distal (>10kb) Multiome | 379 |
Genomic view of the ZNF385D-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.