ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for ZNF322. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF322 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF322, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:26,365,073–26,365,647 | 294.4 kb | Distal (>10kb) Multiome | 587 | |
| chr6:26,382,957–26,383,951 | 276.6 kb | Distal (>10kb) Multiome | 448 | |
| chr6:26,421,258–26,421,866 | 238.3 kb | Distal (>10kb) Multiome | 473 | |
| chr6:26,457,390–26,458,395 | 201.8 kb | Distal (>10kb) Multiome | 525 | |
| chr6:26,473,842–26,474,357 | 185.6 kb | Distal (>10kb) Multiome | 487 | |
| chr6:26,520,324–26,522,398 | 138.8 kb | Distal (>10kb) Multiome | 1082 | |
| chr6:26,532,765–26,533,409 | 126.7 kb | Distal (>10kb) Multiome | 830 | |
| chr6:26,537,180–26,538,912 | 121.4 kb | Distal (>10kb) Multiome | 1114 | |
| chr6:26,550,296–26,550,971 | 109.0 kb | Distal (>10kb) Multiome | 695 | |
| chr6:26,553,165–26,553,642 | 106.2 kb | Distal (>10kb) Multiome | 561 | |
| chr6:26,553,738–26,555,437 | 105.6 kb | Distal (>10kb) Multiome | 779 | |
| chr6:26,556,432–26,557,038 | 103.2 kb | Distal (>10kb) Multiome | 676 | |
| chr6:26,571,613–26,572,233 | 87.8 kb | Distal (>10kb) Multiome | 861 | |
| chr6:26,595,619–26,596,282 | 63.9 kb | Distal (>10kb) Multiome | 798 | |
| chr6:26,596,497–26,597,408 | 62.8 kb | Distal (>10kb) Multiome | 940 | |
| chr6:26,659,338–26,660,351 | 25 bp | At TSS Multiome | 748 | |
| chr6:26,956,244–26,957,132 | 296.6 kb | Distal (>10kb) Multiome | 399 | |
| chr6:27,145,480–27,148,111 | 487.3 kb | Distal (>10kb) Multiome HiCAR | 951 |
Genomic view of the ZNF322 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.