This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for ZNF292. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF292 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF292, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:85,669,340–85,674,412 | 1484.9 kb | Distal (>10kb) Multiome HiCAR | 586 | |
| chr6:86,936,583–86,938,193 | 217.6 kb | Distal (>10kb) Multiome | 406 | |
| chr6:86,943,714–86,944,451 | 210.8 kb | Distal (>10kb) Multiome | 102 | |
| chr6:87,151,562–87,152,822 | 2.7 kb | Proximal (<10kb) Multiome | 359 | |
| chr6:87,154,802–87,156,695 | 483 bp | At TSS Multiome | 1153 | |
| chr6:87,322,367–87,323,025 | 167.6 kb | Distal (>10kb) Multiome | 892 | |
| chr6:87,407,486–87,408,928 | 253.3 kb | Distal (>10kb) Multiome | 735 |
Genomic view of the ZNF292 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.