This gene encodes a member of the zinc finger domain-containing protein family. This family member contains multiple Cys2-His2(C2H2)-type zinc finger domains, the most common type of zinc finger domain that self-folds to form a beta-beta-alpha structure that binds a zinc ion. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for ZNF280C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF280C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF280C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:129,982,008–129,982,922 | 286.4 kb | Distal (>10kb) Multiome | 614 | |
| chrX:129,984,009–129,984,684 | 284.6 kb | Distal (>10kb) Multiome | 240 | |
| chrX:130,060,034–130,061,017 | 208.4 kb | Distal (>10kb) Multiome | 583 | |
| chrX:130,120,389–130,121,207 | 148.0 kb | Distal (>10kb) Multiome | 517 | |
| chrX:130,165,452–130,166,368 | 103.0 kb | Distal (>10kb) Multiome | 754 | |
| chrX:130,170,895–130,171,447 | 97.8 kb | Distal (>10kb) Multiome | 203 | |
| chrX:130,268,321–130,269,066 | 129 bp | At TSS Multiome | 738 | |
| chrX:130,277,260–130,277,622 | 8.4 kb | Proximal (<10kb) | 11 | |
| chrX:130,339,460–130,340,239 | 71.0 kb | Distal (>10kb) Multiome | 548 |
Genomic view of the ZNF280C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.