Enables identical protein binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF250. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF250 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF250, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:144,672,507–144,672,989 | 228.6 kb | Distal (>10kb) Multiome | 150 | |
| chr8:144,684,108–144,686,340 | 217.1 kb | Distal (>10kb) Multiome | 862 | |
| chr8:144,755,078–144,755,956 | 145.9 kb | Distal (>10kb) Multiome | 769 | |
| chr8:144,785,987–144,788,592 | 114.3 kb | Distal (>10kb) Multiome | 997 | |
| chr8:144,791,751–144,793,221 | 109.0 kb | Distal (>10kb) Multiome | 899 | |
| chr8:144,798,389–144,799,501 | 102.5 kb | Distal (>10kb) Multiome | 832 | |
| chr8:144,826,059–144,827,981 | 74.1 kb | Distal (>10kb) Multiome | 905 | |
| chr8:144,852,614–144,853,614 | 48.3 kb | Distal (>10kb) Multiome | 850 | |
| chr8:144,900,754–144,902,675 | 146 bp | At TSS Multiome | 1021 | |
| chr8:144,950,374–144,951,024 | 49.3 kb | Distal (>10kb) Multiome | 695 | |
| chr8:145,002,551–145,003,548 | 101.5 kb | Distal (>10kb) Multiome | 872 | |
| chr8:145,051,576–145,052,751 | 150.9 kb | Distal (>10kb) Multiome | 797 |
Genomic view of the ZNF250 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.