ZNF239

zinc finger protein 239 | HOK-2, MOK2

MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures (Arranz et al., 1997 [PubMed 9121460]).[supplied by OMIM, Mar 2008]

Member of: DE-6 DE-6.9 Developmental clusters: GC4

Biological processes 16 terms

DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA binding (GO:0003723)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear body (GO:0016604)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of gene expression (GO:0010468)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating ZNF239 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF239. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF239 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF239

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF239, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:43,322,425–43,323,518	251.6 kb	Distal (>10kb) Multiome	215
chr10:43,361,820–43,362,935	212.2 kb	Distal (>10kb) Multiome	416
chr10:43,395,694–43,397,607	178.5 kb	Distal (>10kb) Multiome	1120
chr10:43,407,131–43,410,086	165.4 kb	Distal (>10kb) Multiome	1109
chr10:43,420,185–43,421,230	153.9 kb	Distal (>10kb) Multiome	1071
chr10:43,436,316–43,437,609	137.6 kb	Distal (>10kb) Multiome	970
chr10:43,455,021–43,456,361	118.9 kb	Distal (>10kb) Multiome	973
chr10:43,573,680–43,574,942	116 bp	At TSS Multiome	675
chr10:43,606,127–43,607,204	31.9 kb	Distal (>10kb) Multiome	620
chr10:43,648,129–43,649,499	74.3 kb	Distal (>10kb) Multiome	698
chr10:43,689,359–43,690,800	115.6 kb	Distal (>10kb) Multiome	520

Genome Browser

Genomic view of the ZNF239 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.