This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein is a member of the Kruppel family of zinc finger proteins, and contains Kruppel-associated box (KRAB) A and B domains and 15 tandemly arrayed C2H2-type zinc fingers. It is an ortholog of the mouse Zfp93 protein. This gene is located in a cluster of zinc finger genes on 19q13.2. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ZNF235. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF235 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF235, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:44,025,169–44,025,638 | 279.6 kb | Distal (>10kb) Multiome | 531 | |
| chr19:44,051,566–44,052,404 | 253.0 kb | Distal (>10kb) Multiome | 706 | |
| chr19:44,071,747–44,072,437 | 232.9 kb | Distal (>10kb) Multiome | 678 | |
| chr19:44,093,936–44,095,205 | 210.7 kb | Distal (>10kb) Multiome | 671 | |
| chr19:44,112,896–44,114,096 | 191.6 kb | Distal (>10kb) Multiome | 719 | |
| chr19:44,141,264–44,142,208 | 163.4 kb | Distal (>10kb) Multiome | 705 | |
| chr19:44,164,531–44,165,427 | 140.0 kb | Distal (>10kb) Multiome | 754 | |
| chr19:44,207,320–44,207,849 | 97.5 kb | Distal (>10kb) Multiome | 743 | |
| chr19:44,212,226–44,213,003 | 92.5 kb | Distal (>10kb) Multiome | 758 | |
| chr19:44,259,722–44,260,198 | 45.0 kb | Distal (>10kb) Multiome | 622 | |
| chr19:44,304,672–44,305,404 | 41 bp | At TSS Multiome | 703 | |
| chr19:44,356,364–44,357,093 | 51.7 kb | Distal (>10kb) Multiome | 406 | |
| chr19:44,499,680–44,500,955 | 195.6 kb | Distal (>10kb) Multiome | 1007 |
Genomic view of the ZNF235 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.