Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:71,176,306–71,177,119 | 285.5 kb | Distal (>10kb) Multiome | 101 | |
| chr16:71,230,392–71,230,982 | 231.5 kb | Distal (>10kb) Multiome | 194 | |
| chr16:71,288,904–71,289,782 | 172.8 kb | Distal (>10kb) Multiome | 1067 | |
| chr16:71,358,510–71,359,053 | 103.5 kb | Distal (>10kb) Multiome | 387 | |
| chr16:71,412,167–71,413,209 | 49.5 kb | Distal (>10kb) Multiome | 349 | |
| chr16:71,425,887–71,427,162 | 35.7 kb | Distal (>10kb) Multiome | 924 | |
| chr16:71,441,362–71,442,080 | 20.5 kb | Distal (>10kb) Multiome | 232 | |
| chr16:71,461,920–71,462,398 | 1 bp | At TSS Multiome | 944 | |
| chr16:71,484,066–71,484,742 | 22.2 kb | Distal (>10kb) Multiome | 801 | |
| chr16:71,526,040–71,526,860 | 64.2 kb | Distal (>10kb) Multiome | 294 | |
| chr16:71,564,628–71,565,649 | 102.9 kb | Distal (>10kb) Multiome | 792 | |
| chr16:71,625,835–71,627,289 | 164.0 kb | Distal (>10kb) Multiome | 594 | |
| chr16:71,722,829–71,724,442 | 260.9 kb | Distal (>10kb) Multiome | 894 |
Genomic view of the ZNF23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.