Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF226. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF226 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF226, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:43,901,409–43,901,966 | 263.3 kb | Distal (>10kb) Multiome | 528 | |
| chr19:43,934,900–43,935,680 | 229.8 kb | Distal (>10kb) Multiome | 775 | |
| chr19:43,950,951–43,951,533 | 213.9 kb | Distal (>10kb) Multiome | 758 | |
| chr19:43,983,881–43,984,809 | 180.9 kb | Distal (>10kb) Multiome | 634 | |
| chr19:44,002,334–44,003,562 | 162.2 kb | Distal (>10kb) Multiome | 726 | |
| chr19:44,025,169–44,025,638 | 139.7 kb | Distal (>10kb) Multiome | 531 | |
| chr19:44,051,566–44,052,404 | 113.2 kb | Distal (>10kb) Multiome | 706 | |
| chr19:44,071,747–44,072,437 | 93.0 kb | Distal (>10kb) Multiome | 678 | |
| chr19:44,093,936–44,095,205 | 70.8 kb | Distal (>10kb) Multiome | 671 | |
| chr19:44,112,896–44,114,096 | 51.8 kb | Distal (>10kb) Multiome | 719 | |
| chr19:44,141,264–44,142,208 | 23.5 kb | Distal (>10kb) Multiome | 705 | |
| chr19:44,164,531–44,165,427 | 87 bp | At TSS Multiome | 754 | |
| chr19:44,207,320–44,207,849 | 42.4 kb | Distal (>10kb) Multiome | 743 | |
| chr19:44,212,226–44,213,003 | 47.4 kb | Distal (>10kb) Multiome | 758 | |
| chr19:44,259,722–44,260,198 | 94.8 kb | Distal (>10kb) Multiome | 622 | |
| chr19:44,304,672–44,305,404 | 139.9 kb | Distal (>10kb) Multiome | 703 | |
| chr19:44,356,364–44,357,093 | 191.6 kb | Distal (>10kb) Multiome | 406 |
Genomic view of the ZNF226 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.