ZNF212

zinc finger protein 212 | C2H2-150

This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]

Member of: DE-5

Biological processes 18 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)identical protein binding (GO:0042802)neuron apoptotic process (GO:0051402)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)walking behavior (GO:0090659)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating ZNF212 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF212. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF212 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF212

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF212, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:148,940,713–148,941,315	298.6 kb	Distal (>10kb) Multiome	792
chr7:148,966,846–148,967,346	272.6 kb	Distal (>10kb) Multiome	532
chr7:148,982,929–148,984,226	256.0 kb	Distal (>10kb) Multiome	671
chr7:148,987,066–148,988,336	252.1 kb	Distal (>10kb) Multiome	765
chr7:149,027,878–149,029,294	210.9 kb	Distal (>10kb) Multiome	992
chr7:149,065,040–149,066,286	173.8 kb	Distal (>10kb) Multiome	971
chr7:149,071,460–149,072,205	167.7 kb	Distal (>10kb) Multiome	300
chr7:149,090,124–149,091,686	148.9 kb	Distal (>10kb) Multiome	1010
chr7:149,125,518–149,127,217	113.3 kb	Distal (>10kb) Multiome	1147
chr7:149,145,364–149,146,036	94.0 kb	Distal (>10kb) Multiome	220
chr7:149,147,030–149,148,737	92.3 kb	Distal (>10kb) Multiome	938
chr7:149,194,998–149,196,417	44.1 kb	Distal (>10kb) Multiome	917
chr7:149,239,406–149,240,188	8 bp	At TSS Multiome	889
chr7:149,261,689–149,262,807	22.5 kb	Distal (>10kb) Multiome	905
chr7:149,284,774–149,286,087	45.6 kb	Distal (>10kb) Multiome	499
chr7:149,355,344–149,356,078	116.1 kb	Distal (>10kb) Multiome	329
chr7:149,414,692–149,415,889	175.5 kb	Distal (>10kb) Multiome	271
chr7:149,421,846–149,422,651	182.8 kb	Distal (>10kb) Multiome	665
chr7:149,459,399–149,461,328	221.0 kb	Distal (>10kb) Multiome	734
chr7:149,496,856–149,498,276	258.2 kb	Distal (>10kb) Multiome	651

Genome Browser

Genomic view of the ZNF212 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.