Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2003]
Transcription factors with Perturb-seq knockdown data for ZNF181. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF181 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF181, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:34,480,917–34,482,711 | 252.6 kb | Distal (>10kb) Multiome | 520 | |
| chr19:34,501,375–34,501,856 | 232.5 kb | Distal (>10kb) Multiome | 590 | |
| chr19:34,668,047–34,668,472 | 65.8 kb | Distal (>10kb) Multiome | 24 | |
| chr19:34,676,923–34,678,053 | 56.6 kb | Distal (>10kb) Multiome | 728 | |
| chr19:34,727,269–34,727,532 | 6.7 kb | Proximal (<10kb) | 5 | |
| chr19:34,727,713–34,728,120 | 6.1 kb | Proximal (<10kb) | 14 | |
| chr19:34,733,416–34,734,655 | 63 bp | At TSS Multiome | 1008 | |
| chr19:34,772,709–34,773,413 | 38.9 kb | Distal (>10kb) Multiome | 680 | |
| chr19:34,920,040–34,921,057 | 186.3 kb | Distal (>10kb) Multiome | 309 | |
| chr19:34,926,731–34,927,343 | 192.7 kb | Distal (>10kb) Multiome | 741 | |
| chr19:34,963,909–34,964,414 | 229.9 kb | Distal (>10kb) Multiome | 645 | |
| chr19:34,999,304–35,000,970 | 266.0 kb | Distal (>10kb) Multiome | 759 | |
| chr19:35,030,124–35,031,270 | 296.3 kb | Distal (>10kb) Multiome | 534 |
Genomic view of the ZNF181 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.