ZNF174

zinc finger protein 174 | ZSCAN8

This gene encodes a protein with three Cys2-His2-type zinc fingers in the carboxy-terminus, a putative nuclear localization signal, and an amino-terminus SCAN box which forms homodimers. This protein is believed to function as a transcriptional repressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]

Biological processes 18 terms

DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)chromatin (GO:0000785)fibrillar center (GO:0001650)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear body (GO:0016604)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)transcription cis-regulatory region binding (GO:0000976)

Expression (TPM)

TFs regulating ZNF174 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF174. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF174 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF174

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF174, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:3,106,146–3,106,906	294.6 kb	Distal (>10kb) Multiome	851
chr16:3,123,818–3,124,940	276.9 kb	Distal (>10kb) Multiome	800
chr16:3,134,425–3,135,445	266.2 kb	Distal (>10kb) Multiome	752
chr16:3,149,357–3,151,137	250.6 kb	Distal (>10kb) Multiome	975
chr16:3,152,009–3,153,129	248.4 kb	Distal (>10kb) Multiome	889
chr16:3,156,990–3,157,742	243.8 kb	Distal (>10kb) Multiome	680
chr16:3,158,260–3,159,345	242.4 kb	Distal (>10kb) Multiome	764
chr16:3,171,474–3,172,591	229.1 kb	Distal (>10kb) Multiome	574
chr16:3,174,125–3,174,566	226.9 kb	Distal (>10kb) Multiome	371
chr16:3,175,429–3,175,953	225.5 kb	Distal (>10kb) Multiome	483
chr16:3,182,514–3,183,488	218.4 kb	Distal (>10kb) Multiome	690
chr16:3,187,874–3,189,822	211.7 kb	Distal (>10kb) Multiome	679
chr16:3,191,282–3,192,194	209.5 kb	Distal (>10kb) Multiome	509
chr16:3,234,780–3,235,610	166.0 kb	Distal (>10kb) Multiome	845
chr16:3,263,988–3,264,941	136.7 kb	Distal (>10kb) Multiome	923
chr16:3,282,413–3,283,892	118.1 kb	Distal (>10kb) Multiome	964
chr16:3,305,073–3,306,009	95.7 kb	Distal (>10kb) Multiome	681
chr16:3,400,631–3,401,665	112 bp	At TSS Multiome	927
chr16:3,457,535–3,458,643	56.7 kb	Distal (>10kb) Multiome	954
chr16:3,500,701–3,501,337	99.8 kb	Distal (>10kb) Multiome	953
chr16:3,610,900–3,612,357	210.4 kb	Distal (>10kb) Multiome	733
chr16:3,654,171–3,654,861	253.3 kb	Distal (>10kb) Multiome	445

Genome Browser

Genomic view of the ZNF174 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.