Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF133. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF133 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF133, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:17,504,694–17,505,794 | 783.3 kb | Distal (>10kb) Multiome HiCAR | 549 | |
| chr20:18,032,971–18,033,755 | 255.4 kb | Distal (>10kb) Multiome HiCAR | 212 | |
| chr20:18,057,257–18,058,052 | 230.7 kb | Distal (>10kb) Multiome | 323 | |
| chr20:18,058,764–18,059,467 | 229.4 kb | Distal (>10kb) Multiome | 393 | |
| chr20:18,101,249–18,101,961 | 186.9 kb | Distal (>10kb) Multiome | 74 | |
| chr20:18,103,190–18,103,994 | 184.9 kb | Distal (>10kb) Multiome | 149 | |
| chr20:18,137,127–18,138,367 | 150.7 kb | Distal (>10kb) Multiome | 1046 | |
| chr20:18,287,674–18,288,982 | 238 bp | At TSS Multiome | 971 | |
| chr20:18,413,071–18,413,534 | 124.8 kb | Distal (>10kb) Multiome | 167 | |
| chr20:18,466,666–18,467,699 | 178.5 kb | Distal (>10kb) Multiome | 930 | |
| chr20:18,496,758–18,497,430 | 208.6 kb | Distal (>10kb) Multiome | 820 | |
| chr20:18,507,260–18,508,352 | 219.1 kb | Distal (>10kb) Multiome | 959 | |
| chr20:18,566,948–18,567,920 | 278.8 kb | Distal (>10kb) Multiome | 957 | |
| chr20:18,587,564–18,588,839 | 299.4 kb | Distal (>10kb) Multiome | 882 |
Genomic view of the ZNF133 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.