ZMYND8

zinc finger MYND-type containing 8 | KIAA1125, RACK7, PRKCBP1

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Member of: DE-3 Developmental clusters: GC1

Biological processes 40 terms

DNA-binding transcription factor binding (GO:0140297)chromatin (GO:0000785)chromatin organization (GO:0006325)chromosome (GO:0005694)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)dendritic shaft (GO:0043198)dendritic spine (GO:0043197)double-strand break repair via homologous recombination (GO:0000724)histone H3 reader activity (GO:0140006)histone H3K14ac reader activity (GO:0140015)histone H3K4me1 reader activity (GO:0140109)modulation of excitatory postsynaptic potential (GO:0098815)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of cell migration (GO:0030336)negative regulation of transcription by RNA polymerase II (GO:0000122)nervous system development (GO:0007399)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of dendritic spine development (GO:0060999)positive regulation of dendritic spine maintenance (GO:1902952)positive regulation of filopodium assembly (GO:0051491)positive regulation of transcription elongation by RNA polymerase II (GO:0032968)positive regulation of transcription elongation by RNA polymerase II (GO:0032968)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein localization to chromatin (GO:0071168)regulation of DNA-templated transcription (GO:0006355)regulation of postsynaptic density protein 95 clustering (GO:1902897)site of DNA damage (GO:0090734)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)zinc ion binding (GO:0008270)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating ZMYND8 0 TFs

Transcription factors with Perturb-seq knockdown data for ZMYND8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZMYND8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZMYND8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZMYND8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:47,319,319–47,320,069	767 bp	At TSS Multiome HiCAR	412
chr20:47,348,216–47,349,067	29.5 kb	Distal (>10kb) Multiome	230
chr20:47,352,182–47,352,868	33.5 kb	Distal (>10kb) Multiome	352
chr20:47,356,649–47,357,177	37.7 kb	Distal (>10kb) Multiome	667
chr20:47,357,312–47,358,028	38.7 kb	Distal (>10kb) Multiome	996
chr20:47,383,734–47,384,319	65.0 kb	Distal (>10kb) Multiome	786
chr20:47,501,324–47,502,272	182.8 kb	Distal (>10kb) Multiome	1052

Genome Browser

Genomic view of the ZMYND8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.