This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ZMPSTE24. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZMPSTE24 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZMPSTE24, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:40,039,712–40,041,155 | 217.7 kb | Distal (>10kb) Multiome | 992 | |
| chr1:40,096,788–40,097,757 | 161.0 kb | Distal (>10kb) Multiome | 852 | |
| chr1:40,161,107–40,161,976 | 96.9 kb | Distal (>10kb) Multiome | 954 | |
| chr1:40,257,418–40,258,681 | 180 bp | At TSS Multiome | 1088 | |
| chr1:40,315,144–40,317,664 | 57.2 kb | Distal (>10kb) Multiome | 729 | |
| chr1:40,373,298–40,374,444 | 115.4 kb | Distal (>10kb) Multiome | 747 | |
| chr1:40,394,885–40,396,067 | 137.5 kb | Distal (>10kb) Multiome | 153 | |
| chr1:40,449,758–40,450,645 | 191.9 kb | Distal (>10kb) Multiome | 807 | |
| chr1:40,476,972–40,477,791 | 219.1 kb | Distal (>10kb) Multiome | 683 | |
| chr1:40,508,401–40,509,160 | 250.5 kb | Distal (>10kb) Multiome | 805 | |
| chr1:40,531,425–40,532,089 | 273.4 kb | Distal (>10kb) Multiome | 724 |
Genomic view of the ZMPSTE24 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.