This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for ZFYVE26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFYVE26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFYVE26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:67,532,784–67,533,987 | 283.3 kb | Distal (>10kb) Multiome | 684 | |
| chr14:67,541,829–67,542,290 | 274.6 kb | Distal (>10kb) Multiome | 187 | |
| chr14:67,599,595–67,600,617 | 216.4 kb | Distal (>10kb) Multiome | 746 | |
| chr14:67,619,336–67,620,756 | 196.8 kb | Distal (>10kb) Multiome | 794 | |
| chr14:67,674,148–67,675,415 | 141.8 kb | Distal (>10kb) Multiome | 840 | |
| chr14:67,694,763–67,695,985 | 121.7 kb | Distal (>10kb) Multiome | 742 | |
| chr14:67,729,052–67,729,527 | 87.3 kb | Distal (>10kb) Multiome | 407 | |
| chr14:67,816,043–67,817,024 | 40 bp | At TSS Multiome | 712 | |
| chr14:67,819,625–67,820,281 | 3.2 kb | Proximal (<10kb) Multiome | 482 | |
| chr14:67,934,038–67,934,596 | 117.7 kb | Distal (>10kb) Multiome | 380 | |
| chr14:68,816,186–68,816,983 | 1000.1 kb | Distal (>10kb) Multiome HiCAR | 816 |
Genomic view of the ZFYVE26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.