Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in platelet formation; regulation of definitive erythrocyte differentiation; and regulation of gene expression. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZFPM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFPM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFPM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:88,382,901–88,383,561 | 70.0 kb | Distal (>10kb) Multiome | 166 | |
| chr16:88,443,062–88,443,308 | 10.0 kb | Proximal (<10kb) | 579 | |
| chr16:88,452,301–88,456,281 | 2.4 kb | Proximal (<10kb) Multiome | 1032 | |
| chr16:88,461,827–88,462,218 | 8.5 kb | Proximal (<10kb) | 287 | |
| chr16:88,468,411–88,469,072 | 15.5 kb | Distal (>10kb) Multiome | 251 | |
| chr16:88,533,022–88,535,493 | 80.8 kb | Distal (>10kb) Multiome HiCAR | 458 | |
| chr16:88,569,589–88,571,104 | 117.0 kb | Distal (>10kb) Multiome | 904 | |
| chr16:88,634,178–88,635,155 | 181.3 kb | Distal (>10kb) Multiome | 384 | |
| chr16:88,650,385–88,651,684 | 197.8 kb | Distal (>10kb) Multiome | 890 | |
| chr16:88,662,399–88,664,138 | 209.9 kb | Distal (>10kb) Multiome | 943 | |
| chr16:88,686,082–88,687,017 | 233.2 kb | Distal (>10kb) Multiome | 675 | |
| chr16:88,705,859–88,706,820 | 253.1 kb | Distal (>10kb) Multiome | 838 | |
| chr16:88,737,237–88,737,815 | 284.3 kb | Distal (>10kb) Multiome | 619 |
Genomic view of the ZFPM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.