Predicted to enable zinc ion binding activity. Predicted to be involved in RNA processing. Located in nucleus. Part of MTREC complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZFC3H1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFC3H1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFC3H1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:71,438,722–71,441,509 | 224.1 kb | Distal (>10kb) Multiome | 962 | |
| chr12:71,460,389–71,462,756 | 202.8 kb | Distal (>10kb) Multiome | 231 | |
| chr12:71,659,062–71,659,287 | 4.5 kb | Proximal (<10kb) | 10 | |
| chr12:71,659,403–71,659,538 | 4.3 kb | Proximal (<10kb) | 9 | |
| chr12:71,662,923–71,664,744 | 285 bp | At TSS Multiome | 1029 | |
| chr12:71,671,386–71,672,338 | 8.1 kb | Proximal (<10kb) Multiome | 185 | |
| chr12:71,685,622–71,686,597 | 22.4 kb | Distal (>10kb) Multiome | 910 | |
| chr12:71,754,180–71,755,575 | 91.0 kb | Distal (>10kb) Multiome | 892 | |
| chr12:71,839,299–71,840,331 | 175.9 kb | Distal (>10kb) Multiome | 972 | |
| chr12:71,938,597–71,939,301 | 275.1 kb | Distal (>10kb) Multiome | 651 | |
| chr12:71,947,591–71,948,143 | 284.1 kb | Distal (>10kb) Multiome | 370 |
Genomic view of the ZFC3H1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.