This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for ZFAT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFAT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFAT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:134,456,697–134,457,942 | 255.7 kb | Distal (>10kb) Multiome | 301 | |
| chr8:134,709,371–134,709,952 | 3.1 kb | Proximal (<10kb) | 58 | |
| chr8:134,712,242–134,713,803 | 120 bp | At TSS Multiome | 973 | |
| chr8:134,831,398–134,833,334 | 119.4 kb | Distal (>10kb) Multiome | 1010 | |
| chr8:134,939,887–134,940,994 | 227.4 kb | Distal (>10kb) Multiome | 107 |
Genomic view of the ZFAT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.