Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to act upstream of or within several processes, including face development; fibroblast migration; and platelet-derived growth factor receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZFAND5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFAND5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFAND5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:72,149,120–72,150,027 | 215.6 kb | Distal (>10kb) Multiome | 555 | |
| chr9:72,362,421–72,363,136 | 2.1 kb | Proximal (<10kb) | 226 | |
| chr9:72,363,816–72,366,378 | 112 bp | At TSS Multiome | 1078 | |
| chr9:72,366,692–72,366,894 | 1.5 kb | Proximal (<10kb) | 13 | |
| chr9:72,526,861–72,528,101 | 162.3 kb | Distal (>10kb) Multiome | 468 |
Genomic view of the ZFAND5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.