Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZFAND4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFAND4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFAND4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:45,249,912–45,250,539 | 422.8 kb | Distal (>10kb) Multiome HiCAR | 197 | |
| chr10:45,373,156–45,374,935 | 298.7 kb | Distal (>10kb) Multiome | 443 | |
| chr10:45,418,792–45,420,023 | 253.3 kb | Distal (>10kb) Multiome | 338 | |
| chr10:45,594,255–45,595,274 | 78.0 kb | Distal (>10kb) Multiome | 982 | |
| chr10:45,672,004–45,673,546 | 20 bp | At TSS Multiome | 871 | |
| chr10:45,726,765–45,727,627 | 54.4 kb | Distal (>10kb) Multiome | 520 |
Genomic view of the ZFAND4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.