ZDHHC9
zDHHC palmitoyltransferase 9 | CGI-89, DHHC9, ZNF379, ZNF380, CXorf11, ZDHHC10

This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010]

Member of: DE-1 DE-1.2
Biological processes 30 terms
Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)MAPK cascade (GO:0000165)Ras palmitoyltransferase activity (GO:0043849)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)host-mediated activation of viral process (GO:0044794)palmitoyltransferase activity (GO:0016409)palmitoyltransferase activity (GO:0016409)palmitoyltransferase complex (GO:0002178)peptidyl-L-cysteine S-palmitoylation (GO:0018230)peptidyl-L-cysteine S-palmitoylation (GO:0018230)peptidyl-L-cysteine S-palmitoylation (GO:0018230)positive regulation of cGAS/STING signaling pathway (GO:0141111)positive regulation of pyroptotic inflammatory response (GO:0140639)positive regulation of pyroptotic inflammatory response (GO:0140639)post-translational protein modification (GO:0043687)protein binding (GO:0005515)protein targeting to membrane (GO:0006612)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)
Expression (TPM)
ZDHHC9 — as a Regulated Gene

TFs regulating ZDHHC9 0 TFs

Transcription factors with Perturb-seq knockdown data for ZDHHC9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZDHHC9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ZDHHC9

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZDHHC9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chrX:129,742,000–129,742,555 101.5 kb Distal (>10kb) Multiome 163
chrX:129,843,268–129,844,298 6 bp At TSS Multiome 523
chrX:129,905,717–129,906,258 62.2 kb Distal (>10kb) Multiome 664
chrX:129,931,017–129,933,134 88.5 kb Distal (>10kb) Multiome 620
chrX:129,957,138–129,957,761 113.5 kb Distal (>10kb) Multiome 491
chrX:129,961,005–129,961,747 117.5 kb Distal (>10kb) Multiome 424
chrX:129,982,008–129,982,922 138.6 kb Distal (>10kb) Multiome 614
chrX:129,984,009–129,984,684 140.4 kb Distal (>10kb) Multiome 240
chrX:130,060,034–130,061,017 216.6 kb Distal (>10kb) Multiome 583
chrX:130,120,389–130,121,207 277.0 kb Distal (>10kb) Multiome 517

Genome Browser

Genomic view of the ZDHHC9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chrX:129,732,000 – 130,131,207
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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