Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including nuclear receptor-mediated steroid hormone signaling pathway; regulation of protein localization; and regulation of signal transduction. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZDHHC7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZDHHC7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZDHHC7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:84,819,303–84,820,380 | 191.7 kb | Distal (>10kb) Multiome | 496 | |
| chr16:84,841,652–84,842,331 | 169.5 kb | Distal (>10kb) Multiome | 196 | |
| chr16:84,876,654–84,877,363 | 134.5 kb | Distal (>10kb) Multiome | 54 | |
| chr16:85,011,017–85,012,043 | 2 bp | At TSS Multiome | 927 | |
| chr16:85,014,390–85,014,599 | 2.9 kb | Proximal (<10kb) | 48 | |
| chr16:85,027,317–85,028,400 | 16.2 kb | Distal (>10kb) Multiome | 815 | |
| chr16:85,168,707–85,170,441 | 157.6 kb | Distal (>10kb) Multiome | 398 | |
| chr16:85,234,395–85,236,209 | 224.5 kb | Distal (>10kb) Multiome | 706 |
Genomic view of the ZDHHC7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.