Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in protein localization to plasma membrane and protein palmitoylation. Located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZDHHC22. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZDHHC22 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZDHHC22, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:76,913,323–76,913,886 | 228.2 kb | Distal (>10kb) Multiome | 352 | |
| chr14:76,924,332–76,925,072 | 217.1 kb | Distal (>10kb) Multiome | 256 | |
| chr14:76,947,024–76,947,904 | 194.3 kb | Distal (>10kb) Multiome | 690 | |
| chr14:76,955,827–76,957,395 | 185.2 kb | Distal (>10kb) Multiome | 873 | |
| chr14:76,961,044–76,962,678 | 179.8 kb | Distal (>10kb) Multiome | 848 | |
| chr14:76,968,574–76,969,080 | 172.9 kb | Distal (>10kb) Multiome | 311 | |
| chr14:77,024,027–77,024,710 | 117.4 kb | Distal (>10kb) Multiome | 368 | |
| chr14:77,025,547–77,029,182 | 113.0 kb | Distal (>10kb) Multiome | 996 | |
| chr14:77,032,573–77,034,628 | 108.5 kb | Distal (>10kb) Multiome | 917 | |
| chr14:77,040,063–77,040,913 | 101.2 kb | Distal (>10kb) Multiome | 765 | |
| chr14:77,088,297–77,088,792 | 53.3 kb | Distal (>10kb) Multiome | 234 | |
| chr14:77,097,312–77,099,236 | 43.7 kb | Distal (>10kb) Multiome | 948 | |
| chr14:77,124,505–77,125,759 | 16.8 kb | Distal (>10kb) Multiome | 289 | |
| chr14:77,133,765–77,134,060 | 7.7 kb | Proximal (<10kb) | 418 | |
| chr14:77,139,459–77,142,559 | 2.0 kb | Proximal (<10kb) Multiome | 507 | |
| chr14:77,181,185–77,182,207 | 39.9 kb | Distal (>10kb) Multiome | 485 | |
| chr14:77,270,588–77,271,586 | 129.3 kb | Distal (>10kb) Multiome HiCAR | 147 | |
| chr14:77,320,198–77,322,121 | 179.4 kb | Distal (>10kb) Multiome | 915 | |
| chr14:77,376,423–77,377,683 | 235.3 kb | Distal (>10kb) Multiome | 630 |
Genomic view of the ZDHHC22 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.