ZDHHC21

zDHHC palmitoyltransferase 21 | DHHC21, DNZ1, HSPC097

Enables protein-cysteine S-palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4 Developmental clusters: GC7

Biological processes 28 terms

Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)adrenergic receptor signaling pathway (GO:0071875)adrenergic receptor signaling pathway (GO:0071875)endoplasmic reticulum (GO:0005783)nitric oxide metabolic process (GO:0046209)palmitoyltransferase activity (GO:0016409)palmitoyltransferase activity (GO:0016409)peptidyl-L-cysteine S-palmitoylation (GO:0018230)peptidyl-L-cysteine S-palmitoylation (GO:0018230)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)protein targeting to membrane (GO:0006612)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)regulation of establishment of endothelial barrier (GO:1903140)regulation of establishment of endothelial barrier (GO:1903140)regulation of leukocyte adhesion to arterial endothelial cell (GO:1904997)regulation of leukocyte adhesion to arterial endothelial cell (GO:1904997)regulation of vascular associated smooth muscle contraction (GO:0003056)regulation of vascular associated smooth muscle contraction (GO:0003056)

Expression (TPM)

TFs regulating ZDHHC21 0 TFs

Transcription factors with Perturb-seq knockdown data for ZDHHC21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZDHHC21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZDHHC21

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZDHHC21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr9:14,515,530–14,516,217	177.4 kb	Distal (>10kb) Multiome	236
chr9:14,546,850–14,548,008	146.0 kb	Distal (>10kb) Multiome	219
chr9:14,563,500–14,564,741	129.2 kb	Distal (>10kb) Multiome	205
chr9:14,692,495–14,694,738	12 bp	At TSS Multiome	739
chr9:14,698,914–14,699,856	5.6 kb	Proximal (<10kb)	3
chr9:14,700,096–14,700,707	6.8 kb	Proximal (<10kb)	24
chr9:14,700,813–14,702,999	7.5 kb	Proximal (<10kb)	45
chr9:14,703,231–14,704,953	10.0 kb	Proximal (<10kb)	21
chr9:14,707,894–14,718,960	22.7 kb	Distal (>10kb) Multiome	491
chr9:14,722,051–14,724,133	29.5 kb	Distal (>10kb) Multiome	397
chr9:14,746,175–14,747,463	53.7 kb	Distal (>10kb) Multiome	117
chr9:14,752,089–14,753,309	59.2 kb	Distal (>10kb) Multiome	147
chr9:14,909,925–14,910,721	216.9 kb	Distal (>10kb) Multiome	428
chr9:14,992,603–14,993,831	299.9 kb	Distal (>10kb) Multiome	390

Genome Browser

Genomic view of the ZDHHC21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.