Enables signaling adaptor activity. Involved in antiviral innate immune response and positive regulation of defense response to virus by host. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZDHHC11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZDHHC11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZDHHC11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:611,543–612,836 | 230.2 kb | Distal (>10kb) Multiome | 508 | |
| chr5:693,160–693,784 | 149.0 kb | Distal (>10kb) Multiome | 258 | |
| chr5:784,104–785,298 | 57.7 kb | Distal (>10kb) Multiome | 316 | |
| chr5:892,342–893,335 | 50.3 kb | Distal (>10kb) Multiome | 802 | |
| chr5:1,004,572–1,005,613 | 162.5 kb | Distal (>10kb) Multiome | 404 | |
| chr5:1,008,462–1,009,631 | 166.3 kb | Distal (>10kb) Multiome | 276 | |
| chr5:1,102,030–1,102,780 | 259.9 kb | Distal (>10kb) Multiome | 207 | |
| chr5:1,111,233–1,112,367 | 269.5 kb | Distal (>10kb) Multiome | 516 |
Genomic view of the ZDHHC11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.