Enables RNA binding activity. Predicted to be involved in nuclear RNA surveillance. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZCCHC7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZCCHC7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZCCHC7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:36,891,507–36,892,613 | 228.2 kb | Distal (>10kb) Multiome | 158 | |
| chr9:36,985,941–36,986,827 | 134.2 kb | Distal (>10kb) Multiome | 172 | |
| chr9:37,026,066–37,028,063 | 92.8 kb | Distal (>10kb) Multiome | 872 | |
| chr9:37,034,136–37,035,908 | 86.1 kb | Distal (>10kb) Multiome | 387 | |
| chr9:37,036,528–37,038,168 | 82.8 kb | Distal (>10kb) Multiome | 340 | |
| chr9:37,079,324–37,080,475 | 40.8 kb | Distal (>10kb) Multiome | 1035 | |
| chr9:37,119,886–37,121,225 | 146 bp | At TSS Multiome | 1074 | |
| chr9:37,415,054–37,415,560 | 294.8 kb | Distal (>10kb) Multiome | 414 |
Genomic view of the ZCCHC7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.