Predicted to enable nucleic acid binding activity; phosphatidylinositol binding activity; and zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZCCHC14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZCCHC14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZCCHC14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:87,264,671–87,265,109 | 228.1 kb | Distal (>10kb) Multiome | 88 | |
| chr16:87,278,468–87,279,093 | 214.2 kb | Distal (>10kb) Multiome | 284 | |
| chr16:87,305,529–87,306,047 | 187.2 kb | Distal (>10kb) Multiome | 282 | |
| chr16:87,316,905–87,317,759 | 175.6 kb | Distal (>10kb) Multiome | 945 | |
| chr16:87,382,568–87,384,888 | 109.1 kb | Distal (>10kb) Multiome | 1122 | |
| chr16:87,388,081–87,388,660 | 104.6 kb | Distal (>10kb) Multiome | 794 | |
| chr16:87,391,244–87,393,452 | 100.8 kb | Distal (>10kb) Multiome | 1038 | |
| chr16:87,492,670–87,493,484 | 54 bp | At TSS Multiome | 652 | |
| chr16:87,601,726–87,602,537 | 109.3 kb | Distal (>10kb) Multiome | 217 | |
| chr16:87,765,695–87,766,281 | 273.0 kb | Distal (>10kb) Multiome | 846 | |
| chr16:87,777,440–87,778,323 | 284.9 kb | Distal (>10kb) Multiome | 751 | |
| chr16:87,778,885–87,779,577 | 286.3 kb | Distal (>10kb) Multiome | 990 |
Genomic view of the ZCCHC14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.