Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZC3H12C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZC3H12C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZC3H12C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:108,121,137–108,122,070 | 1971.8 kb | Distal (>10kb) Multiome HiCAR | 878 | |
| chr11:108,664,315–108,665,549 | 1428.4 kb | Distal (>10kb) Multiome HiCAR | 672 | |
| chr11:109,865,550–109,866,757 | 227.2 kb | Distal (>10kb) Multiome | 146 | |
| chr11:110,091,940–110,094,243 | 458 bp | At TSS Multiome | 843 | |
| chr11:110,128,005–110,128,732 | 35.0 kb | Distal (>10kb) Multiome | 206 | |
| chr11:110,130,669–110,131,073 | at TSS | At TSS | 223 | |
| chr11:110,173,762–110,174,831 | 80.8 kb | Distal (>10kb) Multiome | 343 | |
| chr11:110,295,762–110,297,308 | 203.3 kb | Distal (>10kb) Multiome | 774 | |
| chr11:110,337,351–110,338,083 | 244.5 kb | Distal (>10kb) Multiome | 209 | |
| chr11:111,511,983–111,513,416 | 1419.4 kb | Distal (>10kb) Multiome HiCAR | 255 | |
| chr11:111,514,437–111,515,063 | 1421.4 kb | Distal (>10kb) Multiome HiCAR | 141 |
Genomic view of the ZC3H12C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.