The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in the proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought to function as a ribonuclease. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for ZC3H12B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZC3H12B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZC3H12B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:64,975,463–64,977,118 | 58.2 kb | Distal (>10kb) Multiome | 419 | |
| chrX:65,034,275–65,035,721 | 72 bp | At TSS Multiome | 496 | |
| chrX:65,195,614–65,196,324 | 161.0 kb | Distal (>10kb) Multiome | 220 | |
| chrX:65,196,676–65,197,847 | 162.4 kb | Distal (>10kb) Multiome | 355 | |
| chrX:65,300,000–65,300,781 | 265.6 kb | Distal (>10kb) Multiome | 111 |
Genomic view of the ZC3H12B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.