Transcription factors with Perturb-seq knockdown data for ZBTB44-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB44-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB44-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:130,068,597–130,071,216 | 245.3 kb | Distal (>10kb) Multiome | 898 | |
| chr11:130,146,013–130,146,727 | 168.5 kb | Distal (>10kb) Multiome | 413 | |
| chr11:130,159,259–130,160,341 | 155.1 kb | Distal (>10kb) Multiome | 309 | |
| chr11:130,314,035–130,315,987 | 195 bp | At TSS Multiome | 766 | |
| chr11:130,378,066–130,378,569 | 63.4 kb | Distal (>10kb) Multiome | 64 | |
| chr11:130,383,295–130,383,854 | 68.6 kb | Distal (>10kb) Multiome | 272 | |
| chr11:130,427,546–130,428,649 | 113.3 kb | Distal (>10kb) Multiome | 234 | |
| chr11:130,448,217–130,449,643 | 133.6 kb | Distal (>10kb) Multiome | 449 | |
| chr11:130,449,732–130,450,570 | 135.2 kb | Distal (>10kb) Multiome | 212 |
Genomic view of the ZBTB44-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.