Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in chromatin. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZBTB37. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB37 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB37, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:172,544,331–172,545,606 | 1323.4 kb | Distal (>10kb) Multiome HiCAR | 138 | |
| chr1:173,669,068–173,669,991 | 198.7 kb | Distal (>10kb) Multiome | 247 | |
| chr1:173,714,634–173,715,651 | 153.3 kb | Distal (>10kb) Multiome | 1013 | |
| chr1:173,824,030–173,825,369 | 43.8 kb | Distal (>10kb) Multiome | 904 | |
| chr1:173,852,512–173,853,711 | 15.3 kb | Distal (>10kb) Multiome | 358 | |
| chr1:173,859,027–173,863,516 | 5.7 kb | Proximal (<10kb) Multiome | 578 | |
| chr1:173,866,947–173,869,294 | 25 bp | At TSS Multiome | 1182 | |
| chr1:174,021,545–174,024,235 | 154.0 kb | Distal (>10kb) Multiome | 1001 | |
| chr1:174,158,556–174,160,514 | 291.1 kb | Distal (>10kb) Multiome | 924 |
Genomic view of the ZBTB37 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.