Transcription factors with Perturb-seq knockdown data for ZBTB11-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB11-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB11-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:101,466,683–101,467,491 | 209.3 kb | Distal (>10kb) Multiome | 289 | |
| chr3:101,512,475–101,513,632 | 163.3 kb | Distal (>10kb) Multiome | 799 | |
| chr3:101,530,192–101,530,904 | 145.9 kb | Distal (>10kb) Multiome | 336 | |
| chr3:101,561,343–101,562,162 | 114.6 kb | Distal (>10kb) Multiome | 783 | |
| chr3:101,573,305–101,575,121 | 102.3 kb | Distal (>10kb) Multiome | 1039 | |
| chr3:101,641,500–101,642,206 | 34.6 kb | Distal (>10kb) Multiome | 397 | |
| chr3:101,724,220–101,725,851 | 48.4 kb | Distal (>10kb) Multiome | 749 | |
| chr3:101,778,676–101,779,992 | 102.9 kb | Distal (>10kb) Multiome | 826 | |
| chr3:101,848,739–101,850,257 | 173.0 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the ZBTB11-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.