Enables telomeric DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in chromosome, telomeric region and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Modules significantly affected by knockdown. ↑ Up = module upregulated upon KD; ↓ Down = module downregulated upon KD.
| Cluster | Dir | NES | padj | Bind | OR | padj (bind) |
|---|
| Module | Dir | NES | #gRNA | padj | Bind | OR | padj (bind) |
|---|
| Submodule | Module | Dir | NES | #gRNA | Bind | OR | padj (bind) |
|---|
Genes likely regulated by ZBTB10 through linked binding evidence in open chromatin. The chart ranks TF-linked genes by their mean Perturb-seq response to ZBTB10 knockdown, with negative coefficients indicating downregulation and positive coefficients indicating upregulation upon knockdown.
Open chromatin elements (ATAC-seq) where ZBTB10 has ChIP-seq or motif footprint binding evidence and which are linked to at least one target gene region.
| Element | Size | Linked genes |
|---|
Transcription factors with Perturb-seq knockdown data for ZBTB10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:80,211,280–80,212,758 | 274.3 kb | Distal (>10kb) Multiome | 216 | |
| chr8:80,231,585–80,232,350 | 254.1 kb | Distal (>10kb) Multiome | 124 | |
| chr8:80,240,457–80,241,089 | 245.4 kb | Distal (>10kb) Multiome HiCAR | 564 | |
| chr8:80,279,352–80,280,425 | 206.5 kb | Distal (>10kb) Multiome HiCAR | 186 | |
| chr8:80,485,418–80,487,796 | 120 bp | At TSS Multiome | 990 | |
| chr8:80,577,972–80,579,389 | 92.3 kb | Distal (>10kb) Multiome | 563 |
Genomic view of the ZBTB10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.