This gene is unusual in that its coding sequence is mostly derived from Charlie-like DNA transposon; however, it does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The encoded protein is conserved among the mammalian Laurasiatheria branch. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]
Transcription factors with Perturb-seq knockdown data for ZBED5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBED5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBED5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:10,735,514–10,736,088 | 122.2 kb | Distal (>10kb) Multiome | 637 | |
| chr11:10,750,622–10,751,770 | 106.9 kb | Distal (>10kb) Multiome | 974 | |
| chr11:10,792,316–10,792,962 | 65.4 kb | Distal (>10kb) Multiome | 530 | |
| chr11:10,807,818–10,809,752 | 49.0 kb | Distal (>10kb) Multiome | 1038 | |
| chr11:10,857,279–10,858,931 | 82 bp | At TSS Multiome | 958 | |
| chr11:10,930,673–10,932,142 | 73.3 kb | Distal (>10kb) Multiome | 512 | |
| chr11:10,933,806–10,934,381 | 76.0 kb | Distal (>10kb) Multiome | 447 |
Genomic view of the ZBED5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.