This gene belongs to a class of genes that arose through hAT DNA transposition and that encode regulatory proteins. This gene is upregulated in lung cancer tissues, where the encoded protein causes an accumulation of beta-catenin and enhanced lung cancer cell invasion. In addition, the encoded protein can be secreted and be involved in resistance to insulin. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for ZBED3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBED3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBED3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:76,808,093–76,808,802 | 278.8 kb | Distal (>10kb) Multiome | 237 | |
| chr5:76,818,476–76,819,940 | 268.3 kb | Distal (>10kb) Multiome | 686 | |
| chr5:76,953,306–76,954,445 | 133.4 kb | Distal (>10kb) Multiome | 235 | |
| chr5:77,030,193–77,031,058 | 56.8 kb | Distal (>10kb) Multiome | 903 | |
| chr5:77,076,843–77,078,059 | 9.6 kb | Proximal (<10kb) Multiome | 396 | |
| chr5:77,086,556–77,087,540 | 297 bp | At TSS Multiome | 768 | |
| chr5:77,210,182–77,211,717 | 123.2 kb | Distal (>10kb) Multiome | 287 |
Genomic view of the ZBED3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.