This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for YWHAZ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YWHAZ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YWHAZ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:100,720,634–100,723,228 | 231.0 kb | Distal (>10kb) Multiome | 1037 | |
| chr8:100,809,500–100,810,195 | 143.5 kb | Distal (>10kb) Multiome | 204 | |
| chr8:100,847,178–100,847,780 | 105.8 kb | Distal (>10kb) Multiome | 682 | |
| chr8:100,907,969–100,909,029 | 44.8 kb | Distal (>10kb) Multiome | 553 | |
| chr8:100,950,243–100,953,706 | 397 bp | At TSS Multiome | 1156 | |
| chr8:101,041,585–101,042,308 | 88.5 kb | Distal (>10kb) Multiome | 191 | |
| chr8:101,078,982–101,079,657 | 125.9 kb | Distal (>10kb) Multiome | 157 | |
| chr8:101,080,237–101,081,347 | 127.6 kb | Distal (>10kb) Multiome | 546 | |
| chr8:101,126,053–101,127,200 | 173.3 kb | Distal (>10kb) Multiome HiCAR | 618 | |
| chr8:101,137,220–101,137,790 | 184.0 kb | Distal (>10kb) Multiome HiCAR | 578 | |
| chr8:101,204,668–101,206,670 | 252.3 kb | Distal (>10kb) Multiome | 1036 |
Genomic view of the YWHAZ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.