YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon | FLJ45465

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]

Member of: DE-1 DE-1.5
Biological processes 61 terms
MAPK cascade (GO:0000165)MHC class II protein complex binding (GO:0023026)RNA binding (GO:0003723)cadherin binding (GO:0045296)calcium channel inhibitor activity (GO:0019855)calcium channel regulator activity (GO:0005246)cellular response to heat (GO:0034605)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)enzyme binding (GO:0019899)extracellular exosome (GO:0070062)focal adhesion (GO:0005925)histone deacetylase binding (GO:0042826)identical protein binding (GO:0042802)identical protein binding (GO:0042802)intracellular potassium ion homeostasis (GO:0030007)intracellular protein localization (GO:0008104)intracellular signal transduction (GO:0035556)melanosome (GO:0042470)membrane (GO:0016020)membrane repolarization during cardiac muscle cell action potential (GO:0086013)mitochondrial membrane (GO:0031966)molecular function inhibitor activity (GO:0140678)negative regulation of calcium ion export across plasma membrane (GO:1905913)negative regulation of protein import into nucleus (GO:0042308)negative regulation of toll-like receptor signaling pathway (GO:0034122)nucleus (GO:0005634)nucleus (GO:0005634)phosphoprotein binding (GO:0051219)phosphoserine residue binding (GO:0050815)phosphoserine residue binding (GO:0050815)plasma membrane (GO:0005886)positive regulation of hippo signaling (GO:0035332)positive regulation of protein export from nucleus (GO:0046827)potassium channel regulator activity (GO:0015459)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein heterodimerization activity (GO:0046982)protein localization to endoplasmic reticulum (GO:0070972)protein localization to nucleus (GO:0034504)protein phosphatase binding (GO:0019903)protein phosphatase inhibitor activity (GO:0004864)protein sequestering activity (GO:0140311)regulation of cytosolic calcium ion concentration (GO:0051480)regulation of heart rate by cardiac conduction (GO:0086091)regulation of heart rate by hormone (GO:0003064)regulation of membrane repolarization (GO:0060306)regulation of mitotic cell cycle (GO:0007346)regulation of potassium ion transmembrane transport (GO:1901379)scaffold protein binding (GO:0097110)signal transduction (GO:0007165)signaling adaptor activity (GO:0035591)substantia nigra development (GO:0021762)transmembrane transporter binding (GO:0044325)ubiquitin protein ligase binding (GO:0031625)
Expression (TPM)
YWHAE — as a Regulated Gene

TFs regulating YWHAE 0 TFs

Transcription factors with Perturb-seq knockdown data for YWHAE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YWHAE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to YWHAE

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YWHAE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:1,109,073–1,109,822 290.7 kb Distal (>10kb) Multiome 401
chr17:1,179,265–1,180,687 220.2 kb Distal (>10kb) Multiome 303
chr17:1,187,041–1,187,512 212.9 kb Distal (>10kb) Multiome 361
chr17:1,202,976–1,204,162 196.8 kb Distal (>10kb) Multiome 420
chr17:1,210,129–1,211,219 189.5 kb Distal (>10kb) Multiome 35
chr17:1,268,002–1,268,635 131.9 kb Distal (>10kb) Multiome 644
chr17:1,399,339–1,400,718 31 bp At TSS Multiome 879
chr17:1,455,335–1,456,916 56.1 kb Distal (>10kb) Multiome 879
chr17:1,484,963–1,486,119 85.1 kb Distal (>10kb) Multiome 562
chr17:1,487,906–1,488,733 88.0 kb Distal (>10kb) Multiome 597
chr17:1,490,717–1,492,156 91.3 kb Distal (>10kb) Multiome 675
chr17:1,515,722–1,517,330 116.6 kb Distal (>10kb) Multiome 796
chr17:1,562,314–1,563,047 162.6 kb Distal (>10kb) Multiome 685
chr17:1,589,843–1,590,457 189.9 kb Distal (>10kb) Multiome 538
chr17:1,627,811–1,629,617 228.5 kb Distal (>10kb) Multiome 753
chr17:1,642,697–1,644,482 243.1 kb Distal (>10kb) Multiome 467
chr17:1,648,163–1,650,244 248.9 kb Distal (>10kb) Multiome 932
chr17:1,684,343–1,685,342 284.7 kb Distal (>10kb) Multiome 728

Genome Browser

Genomic view of the YWHAE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:1,099,073 – 1,695,342
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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