YTHDF1

YTH N6-methyladenosine RNA binding protein F1 | FLJ20391, C20orf21

Enables N6-methyladenosine-containing RNA reader activity and ribosome binding activity. Involved in mRNA destabilization; positive regulation of translational initiation; and stress granule assembly. Located in P-body and cytoplasmic stress granule. Implicated in colorectal cancer. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 38 terms

N6-methyladenosine-containing RNA reader activity (GO:1990247)N6-methyladenosine-containing RNA reader activity (GO:1990247)N6-methyladenosine-containing RNA reader activity (GO:1990247)P-body (GO:0000932)P-body (GO:0000932)RNA binding (GO:0003723)RNA binding (GO:0003723)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic stress granule (GO:0010494)cytoplasmic stress granule (GO:0010494)learning (GO:0007612)learning (GO:0007612)mRNA binding (GO:0003729)mRNA destabilization (GO:0061157)mRNA destabilization (GO:0061157)mRNA destabilization (GO:0061157)memory (GO:0007613)memory (GO:0007613)organelle assembly (GO:0070925)positive regulation of translation (GO:0045727)positive regulation of translation (GO:0045727)positive regulation of translational initiation (GO:0045948)positive regulation of translational initiation (GO:0045948)protein binding (GO:0005515)regulation of antigen processing and presentation (GO:0002577)regulation of antigen processing and presentation (GO:0002577)regulation of axon guidance (GO:1902667)regulation of axon guidance (GO:1902667)regulation of long-term synaptic potentiation (GO:1900271)regulation of long-term synaptic potentiation (GO:1900271)regulation of mRNA stability (GO:0043488)regulation of mRNA stability (GO:0043488)ribosome binding (GO:0043022)stress granule assembly (GO:0034063)stress granule assembly (GO:0034063)stress granule assembly (GO:0034063)

Expression (TPM)

TFs regulating YTHDF1 0 TFs

Transcription factors with Perturb-seq knockdown data for YTHDF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YTHDF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to YTHDF1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YTHDF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:62,925,950–62,926,856	289.6 kb	Distal (>10kb) Multiome	874
chr20:62,928,980–62,929,573	286.8 kb	Distal (>10kb) Multiome	289
chr20:62,937,285–62,938,569	278.1 kb	Distal (>10kb) Multiome	1026
chr20:63,006,367–63,007,246	209.2 kb	Distal (>10kb) Multiome	189
chr20:63,071,594–63,072,696	144.2 kb	Distal (>10kb) Multiome	246
chr20:63,178,716–63,179,743	36.9 kb	Distal (>10kb) Multiome	386
chr20:63,215,706–63,216,790	127 bp	At TSS Multiome	965
chr20:63,272,274–63,273,137	56.6 kb	Distal (>10kb) Multiome	736
chr20:63,409,631–63,410,124	193.7 kb	Distal (>10kb) Multiome	60
chr20:63,471,533–63,472,788	256.5 kb	Distal (>10kb) Multiome	219
chr20:63,488,166–63,488,632	272.3 kb	Distal (>10kb) Multiome	127
chr20:63,498,850–63,499,391	283.1 kb	Distal (>10kb) Multiome	232

Genome Browser

Genomic view of the YTHDF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.