Enables L-threonylcarbamoyladenylate synthase. Involved in tRNA threonylcarbamoyladenosine modification. Acts upstream of or within negative regulation of transport. Is active in mitochondrion. Implicated in Galloway-Mowat syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for YRDC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YRDC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YRDC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:37,513,871–37,515,291 | 293.4 kb | Distal (>10kb) Multiome | 884 | |
| chr1:37,553,845–37,554,497 | 253.9 kb | Distal (>10kb) Multiome | 748 | |
| chr1:37,556,626–37,557,247 | 251.3 kb | Distal (>10kb) Multiome | 284 | |
| chr1:37,595,631–37,596,377 | 212.2 kb | Distal (>10kb) Multiome | 754 | |
| chr1:37,634,598–37,635,064 | 173.4 kb | Distal (>10kb) Multiome | 192 | |
| chr1:37,663,328–37,663,865 | 144.6 kb | Distal (>10kb) Multiome | 44 | |
| chr1:37,690,078–37,690,919 | 117.6 kb | Distal (>10kb) Multiome | 679 | |
| chr1:37,691,459–37,692,843 | 115.8 kb | Distal (>10kb) Multiome | 781 | |
| chr1:37,752,766–37,753,277 | 55.1 kb | Distal (>10kb) Multiome | 223 | |
| chr1:37,793,768–37,794,528 | 14.1 kb | Distal (>10kb) Multiome | 567 | |
| chr1:37,807,583–37,809,057 | 3 bp | At TSS Multiome | 755 | |
| chr1:37,811,169–37,811,366 | 3.0 kb | Proximal (<10kb) | 227 | |
| chr1:37,859,081–37,860,381 | 51.5 kb | Distal (>10kb) Multiome | 939 | |
| chr1:37,931,446–37,932,215 | 123.7 kb | Distal (>10kb) Multiome | 559 | |
| chr1:37,946,605–37,947,220 | 138.8 kb | Distal (>10kb) Multiome | 610 | |
| chr1:37,989,644–37,990,549 | 181.9 kb | Distal (>10kb) Multiome | 1133 | |
| chr1:37,995,790–37,996,610 | 188.0 kb | Distal (>10kb) Multiome | 313 | |
| chr1:38,004,771–38,006,024 | 197.4 kb | Distal (>10kb) Multiome | 442 | |
| chr1:38,012,220–38,013,284 | 204.4 kb | Distal (>10kb) Multiome | 1074 | |
| chr1:38,030,338–38,030,974 | 222.3 kb | Distal (>10kb) Multiome | 225 | |
| chr1:38,045,344–38,048,035 | 238.8 kb | Distal (>10kb) Multiome | 542 |
Genomic view of the YRDC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.